Our researchers are leading seminal work on pharmacogenetic testing for asthma, performing genetic epidemiological studies that focus on large, real-life populations. Highlights include:
- A study that evaluated the effectiveness of recently developed pharmacogenetic tests that predict which patients are at highest risk for not responding to the two most commonly used medications for asthma, B2-agonist and inhaled corticosteroids.
- A current NHLBI funded study to validate a pharmacogenetic test using a cohort of asthma patients who have been treated with inhaled corticosteroids.
- A new NHGRI R21 grant co-led by Dr. Ann Wu to study access and reimbursement issues relating to guideline-recommended pharmacogenomic tests and the implications of barriers to access and/or differential access. This study could ultimately help policy makers develop coverage policies to optimize affordable and equitable access to guideline-recommended genomics-based technologies in order to improve population health.
- Kelly RS, Dahlin A, McGeachie MJ, et al. Asthma Metabolomics and the Potential for Integrative Omics in Research and the Clinic. CHEST. Feb 2017;151(2):262-277.
- McGeachie MJ, Dahlin A, Qiu W, Croteau-Chonka DC, Savage J, Wu AC, Wan ES, Sordillo JE, Al-Garawi A, Martinez FD, Strunk RC, Lemanske RF Jr, Liu AH, Raby BA, Weiss S, Clish CB, Lasky-Su JA. The metabolomics of asthma control: a promising link between genetics and disease. Immun Inflamm Dis. 2015 Sep;3(3):224-38. Epub 2015 May 7.
- McGeachie MJ, Wu AC, Tse SM, Clemmer GL, Sordillo J, Himes BE, Lasky-Su J, Chase RP, Martinez FD, Weeke P, Shaffer CM, Xu H, Denny JC, Roden DM, Panettieri RA Jr, Raby BA, Weiss ST, Tantisira KG. CTNNA3 and SEMA3D: Promising loci for asthma exacerbation identified through multiple genome-wide association studies. J Allergy Clin Immunol. 2015 Jun 12. [Epub ahead of print]
- Clemmer GL, Wu AC, Rosner B, McGeachie MJ, Litonjua AA, Tantisira KG, Weiss ST. Measuring the corticosteroid responsiveness endophenotype in asthmatic patients. J Allergy Clin Immunol. 2015 Aug;136(2):274-81.e8. Epub 2015 May 5.
- Wu AC, Gay C, Rett MD, Stout N, Weiss ST, Fuhlbrigge AL. Pharmacogenomic test that predicts response to inhaled corticosteroids in adults with asthma likely to be cost-saving. Pharmacogenomics. 2015;16(6):591-600. Epub 2015 Apr 16.
- Wu AC, Himes BE, Lasky-Su J, Litonjua A, Peters SP, Lima J, Kubo M, Tamari M, Nakamura Y, Qiu W, Weiss ST, Tantisira K. Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics. J Allergy Clin Immunol. 2014 Mar;133(3):723-8.e3. Epub 2013 Nov 23.